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In a study in the 5XFAD mouse model of AD, microbial dysbiosis was noted to be associated with activation of the endolysosomal CCAAT/enhancer-binding protein- (C/EBP-) asparagine endopeptidase (AEP) pathway (Chen et al., 2020)

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Weight loss: About 10.8% body-weight reduction at 4.5 mg over 26 weeks in phase 2 [1]